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Image Search Results
Journal: European journal of medicinal chemistry
Article Title: Enhanced tumor retention of NTSR1-targeted agents by employing a hydrophilic cysteine cathepsin inhibitor
doi: 10.1016/j.ejmech.2019.05.068
Figure Lengend Snippet: Synthetic Procedures for 1a and 1ba aReagents and conditions: (a) (i) EDCI, NHS, DMF, 0°C, 2-3h (ii) 2-azidoethanamine, DIEA,DMF, r.t., overnight; (b) (i) 20% piperidine in DMF, r.t., 30min; (ii) COMU, Fmoc-Leu-OH, DIEA, DMF, r.t., 2h; (c) (i) 20% piperidine in DMF, r.t., 30min; (ii) COMU, (+/−)-trans-oxirane-2,3-dicarboxylic acid, DMF, DIEA, r.t., overnight; (c) (i) 20% piperidine in DMF, r.t., 30min; succinic anhydride, TEA, DMF, 50°C, overnight; (e) 90% TFA in DCM, r.t., 2h.
Article Snippet: Fluorenylmethyloxycarbonyl (Fmoc)-protected natural amino acids,
Techniques: